A marked isotype switch to cytophilic (immunoglobulin G1 [IgG1]/IgG3) antibodies was evident with increasing exposure exclusively in occupants from areas of endemicity. Asexual blood stages of thePlasmodiumlife cycle are responsible for the acute symptoms of malaria. high prevalence of natural antibodies toP. falciparumAMA-1 has been shown in populations with lifelong exposure to malaria (10,14,16), but […]