Administration of the miR-15a/16-1 antagomirs significantly reduced mRNA levels of these pro-inflammatory cytokines in the ischemic cortex 24h or 72h after MCAO compared to the scramble control (Supplemental Physique VI, Fig. of miR-15a/16-1 activity, major pro-inflammatory cytokines were measured by qPCR or ELISA and anti-apoptotic proteins were examined by western blotting. Results Genetic deletion of […]