Then cells were placed on ice, washed, and cell lysis was performed. both and co-injection of HPSE2 along with LPS in mice led to decreased cytokines expression in plasma. In polymicrobial CLP mouse sepsis model the expression of HPSE2 in renal medullary capillaries was decreased. Thus, loss of HPSE2 can promote microcirculatory disorder in sepsis […]